Endothermy, ie the endogenous production of metabolic heat, has evolved multiple times
among vertebrates, and several strategies of heat production have been studied extensively …

The worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in
adults but also in children and adolescents. Diabetes is associated with macrovascular …

Uncoupling protein 1 (UCP1) is localized on the inner mitochondrial membrane and
generates heat by uncoupling ATP synthesis from proton transit across the inner membrane …

The field of comparative ageing biology has greatly expanded in the past 20 years.
Longitudinal studies of populations of reptiles with a range of maximum lifespans have …

To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16
brains from 14 cetartiodactyl species, with immunohistochemical techniques, for evidence of …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine …

Uncoupling protein 1 (UCP1) permits non-shivering thermogenesis (NST) when highly
expressed in brown adipose tissue (BAT) mitochondria. Exclusive to placental mammals …

Energy metabolism is determined by a suite of regulatory mechanism, and their increasing
complexity over evolutionary time provides the key to understanding the emergence of …

Beige adipocytes are a distinct type of fat cells with a thermogenic activity that have gained
substantial attention as an alternative cellular anti-obesity target in humans. These cells may …

Endothermy changes the relationship between organisms and their environment
fundamentally, and it is therefore of major ecological and evolutionary significance …