Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …

The anti-epileptic drug lamotrigine (LTG) has been widely used to treat various neurological
disorders, including epilepsy and bipolar disorder. However, its precise mechanism of action …

Inhibition-induced enhancement or paradoxical response of firing was related to Hopf
bifurcation instead of saddle-node bifurcation on an invariant cycle (SNIC), due to the" …

Missense variants of hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) ion
channels cause variable phenotypes, ranging from mild generalized epilepsy to …

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are promising
therapeutic targets because of their association with the genesis of several diseases. The …

Transmembrane proteins known as hyperpolarization-activated cyclic nucleotide-gated
(HCN) channels control the movement of Na+ and K+ ions across cellular membranes. HCN …

Over 50 million people worldwide are affected by epilepsy, a common neurological disorder
that has a high rate of drug resistance and diverse comorbidities such as progressive …

Pathogenic variants in genes encoding ion channels are causal for various pediatric and
adult neurological conditions. In particular, several epilepsy syndromes have been identified …

Hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) is
predominantly expressed in neurons from the neocortex and hippocampus, two important …