Thrombosis is the underlying cause of a host of common, debilitating, and often fatal
cardiovascular disorders. Formation of thrombi in the arterial circulation can lead to acute …

To prevent thromboses after surgery, patients have until now had to inject themselves daily
with heparin. For stroke prophylaxis in atrial fibrillation, patients take vitamin K antagonists of …

As part of the Community Structure-Activity Resource (CSAR) center, a set of 343 high-
quality, protein–ligand crystal structures were assembled with experimentally determined K …

An efficient Suzuki cross-coupling protocol enables the reaction of N-hetero and normal aryl
chlorides with thiophene-and furanboronic acids. Coupling is effected in aqueous n-butanol …

Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were
performed by modifying each of the three phenyl rings. A class of highly potent, selective …

Abstract A dicyclohexyl (2‐sulfo‐9‐(3‐(4‐sulfophenyl) propyl)‐9H‐fluoren‐9‐yl)
phosphonium salt was synthesized in 64% overall yield in three steps from simple …

As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …

Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial
infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized …

CB2R are fascinating targets for neuropathic pain and mood disorders because of their
improved biological characteristics. Experimental data on 1296 cannabinoid-2 receptor …

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were
designed and synthesized as a part of our ongoing search for potential anticancer agents …