Major depression is multifactorial disorder with high prevalence and alarming prognostic in
the nearest 15 years. Several mechanisms of depression are known. Neurotransmitters …

Anxiety disorders are the most common mental illness in the USA affecting 18% of the
population. The cause (s) of anxiety disorders is/are not completely clear, and research in …

Background Abundant researches indicate that neuroinflammation has important roles in the
pathophysiology of depression. Our previous study found that the NLRP3 inflammasome …

A combination of different risk factors, such as genetic, environmental and psychological
factors, together with immune system, stress response, brain neuroplasticity and the …

Depression is one of the most common mood disorders with a high rate of relapse.
Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived …

Berberine, a natural isoquinoline alkaloid, is used in herbal medicine and has recently been
shown to have efficacy in the treatment of mood disorders. Furthermore, berberine …

The present study aimed to review major depression, including its types, epidemiology,
association with different diseases status and treatments, as well as its correlation with the …

Several studies have shown that Nrf2, a major redox-sensitive transcription factor involved in
the cellular defense against oxidative stress, increases susceptibility to depressive-like …

There is increasing interest in the involvement of antioxidative systems in protecting from
depression. Among these, Nrf2 occupies a central place. We aimed to review the role of Nrf2 …

Historically the monoaminergic neurotransmitter system, in particular the serotonergic
system, was seen as being responsible for the pathophysiology of major depressive …