Summary Background Alpha-1 Antitrypsin (AAT) deficiency (AATD), the most common
genetic cause of emphysema presents with unexplained phenotypic heterogeneity in …

Rationale: CC16 is a protein mainly produced by nonciliated bronchial epithelial cells
(BECs) that participates in host defense. Reduced CC16 protein concentrations in BAL and …

To explore the role of extracellular vesicles (EVs) in chronic lung diseases. EVs are
emerging as mediators of intercellular communication and possible diagnostic markers of …

In patients with chronic obstructive pulmonary disease (COPD), cardiovascular
comorbidities are highly prevalent and associated with considerable morbidity and mortality …

Background Multiple gene expression studies have been performed separately in peripheral
blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene …

Purpose Muscle atrophy is a major clinical feature of chronic obstructive pulmonary disease
(COPD) and is considered a predictor of mortality in COPD patients. Recently, the cross …

Globally, chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity
and mortality, having a significant socioeconomic effect. Several molecular mechanisms …

Rationale COPD has been associated repeatedly with single biomarkers of systemic
inflammation, ignoring the complexity of inflammatory pathways. This study aimed to cluster …

Background Previous studies on acute exacerbation of chronic obstructive pulmonary
disease (AECOPD) have found that those who died in hospital had higher blood urea …

Background COPD is one of the leading causes of morbidity and mortality in the world;
however, the most varied amounts of clinical and laboratory characteristics acts in different …