Transcriptional profiling of circulating mononuclear cells from patients with chronic obstructive pulmonary disease receiving mesenchymal stromal cell infusions

JD Armitage, DBA Tan, M Sturm… - Stem Cells …, 2021 - academic.oup.com
Chronic obstructive pulmonary disease (COPD) is an inflammatory airways disease with
limited therapeutic options. We have previously shown that mesenchymal stromal cell (MSC) …

Multiparametric quantitative imaging biomarker as a multivariate descriptor of health: a roadmap

DL Raunig, GA Pennello, JG Delfino, AJ Buckler… - Academic radiology, 2023 - Elsevier
Multiparametric quantitative imaging biomarkers (QIBs) offer distinct advantages over single,
univariate descriptors because they provide a more complete measure of complex …

The potential of digital molecular diagnostics for infectious diseases in sub-Saharan Africa

Digital Diagnostics for Africa Network - PLOS Digital Health, 2022 - journals.plos.org
There is a large gap between diagnostic needs and diagnostic access across much of sub-
Saharan Africa (SSA), particularly for infectious diseases that inflict a substantial burden of …

Development of multiple biomarker panels for prediction of sarcopenia in community-dwelling older adults

HE Shin, CW Won, M Kim - Archives of Gerontology and Geriatrics, 2023 - Elsevier
Background It is required to consider multiple biomarkers simultaneously to predict
sarcopenia and to understand its complex pathological mechanisms. This study aimed to …

Biomarkers of acute lung injury the individualized approach: for phenotyping, risk stratification and treatment surveillance

DD Murray, TS Itenov, P Sivapalan, JV Eklöf… - Journal of clinical …, 2019 - mdpi.com
Do we need biomarkers of lung damage and infection: For what purpose and how should
they be used properly? Biomarkers of lung damage can be used for diagnosis, risk …

Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD

R Bowler, M Allinder, S Jacobson… - BMJ Open …, 2019 - bmjopenrespres.bmj.com
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
characterised by airflow obstruction and other morbidities such as respiratory symptoms …

Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans

F Klont, P Horvatovich, RP Bowler, E van Rikxoort… - Respiratory …, 2022 - Springer
Background There is a strong need for biomarkers to better characterize individuals with
COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has …

Affimers as an alternative to antibodies in an affinity LC–MS assay for quantification of the soluble receptor of advanced glycation end-products (sRAGE) in human …

F Klont, M Hadderingh, P Horvatovich… - Journal of proteome …, 2018 - ACS Publications
Antibodies are indispensable tools in biomedical research, but their size, complexity, and
sometimes lack of reproducibility created a need for the development of alternative binders …

Association of air pollution exposure with exercise-induced oxygen desaturation in COPD

KY Lee, SM Wu, HY Kou, KY Chen, HC Chuang… - Respiratory …, 2022 - Springer
Background There is a link between exposure to air pollution and the increased prevalence
of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the …

Predicting Lung Function Using Biomarkers in Alpha-1 Antitrypsin Deficiency

DA Spittle, A Mansfield, A Pye, AM Turner, M Newnham - Biomedicines, 2023 - mdpi.com
Lung disease progression in alpha-1 antitrypsin deficiency (AATD) is heterogenous and
manifests in different ways. Blood biomarkers are an attractive method of monitoring …