Cisplatin, carboplatin and oxaliplatin are some of the most widely used anti-cancer agents in
solid tumours. The cytotoxicity of platinating agents is directly related to their ability to cause …

Purpose Understanding how specific genetic variants modify drug action pathways may
provide informative blueprints for individualized chemotherapy. Methods We applied a …

Cisplatin is a valuable adjuvant to radiotherapy for the treatment of cervical cancer. Because
the advantage of combining cisplatin with radiotherapy is likely to be attributable to additive …

Abstract Background. The Avastin® Registry: Investigation of Effectiveness and Safety
(ARIES) study is a prospective, community-based observational cohort study that evaluated …

The excision repair cross-complementation group 1 (ERCC1) enzyme plays a rate-limiting
role in the nucleotide excision repair pathway and is associated with resistance to platinum …

Purpose: We prospectively evaluated the predictive value of positron emission tomography
using fluorine-18 fluorodeoxyglucose (FDG-PET) for in vivo testing of chemosensitivity in …

Artificial devices such as the synthetic riboswitch have shown potential to introduce
unnatural phenotypic perturbation because its synthetic traits are distinct from that of innate …

BACKGROUND: Genetic polymorphisms involved in DNA repair and apoptosis are
suspected to influence patient response to cancer treatment. To evaluate the effect of …

PURPOSE: The aim of this study was to determine the prognostic value of expression of ATP
binding cassette (ABC) transporter proteins and DNA repair gene proteins by …

It is well accepted that expression of mutant p53 involves the gain of oncogenic-specific
activities accentuating the malignant phenotype. Depending on the specific cancer type …