Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Telomere attrition is considered a hallmark of ageing. Untangling the proximate causes of
telomere attrition may therefore reveal important aspects about the ageing process. In a …

Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …

Intervertebral disc degeneration (IVDD) is a frequent and intractable chronic condition in
orthopedics that causes enormous discomfort in patients' lives and thoughts, as well as a …

Telomere attrition is a proposed hallmark of aging. To evaluate the association of telomere
length (TL) with chronological age across the human lifespan, we conducted a systematic …

Cellular senescence constitutes a stress response mechanism in reaction to a plethora of
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …