Reprogrammed metabolism is a hallmark of cancer. However, the metabolic dependency of
cancer, from tumour initiation through disease progression and therapy resistance, requires …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Cell senescence has been implicated in the pathology of Parkinson's disease (PD). Both
abnormal α-synuclein aggregation and iron deposition are suggested to be the triggers …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

Aging is a complex process characterized by an ongoing decline in physiological functions,
leading to degenerative diseases and an increased probability of death. Cellular …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Background Prostate cancer threatens the health of men over sixty years old, and its
incidence ranks first among all urinary tumors among men. Enzalutamide remains the first …