Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

One of the challenges raised by next generation sequencing (NGS) is the identification of
clinically relevant mutations among all the genetic variation found in an individual. Network …

High-throughput,'omic'methods provide sensitive measures of biological responses to
perturbations. However, inherent biases in high-throughput assays make it difficult to …

Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …

Drugs bind to their target proteins, which interact with downstream effectors and ultimately
perturb the transcriptome of a cancer cell. These perturbations reveal information about their …

Similarities and differences in the associations of biological entities among species can
provide us with a better understanding of evolutionary relationships. Often the evolution of …

Motivation: It has long been hypothesized that incorporating models of network noise as well
as edge directions and known pathway information into the representation of protein–protein …

The protein-protein interaction (PPI) network of an organism serves as a skeleton for its
signaling circuitry, which mediates cellular response to environmental and genetic cues …

Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet
knowledge of the complete stress‐activated regulatory network as well as design principles …

If the genome defines the program for the operations of a cell, signaling networks execute it.
These cascades of chemical, cell-biological, structural, and trafficking events span …