Sex differences in opioid and psychostimulant craving and relapse: a critical review
A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …
than males to drug craving and relapse. Here, we first review clinical studies on sex …
Regulation of cocaine-related behaviours by estrogen and progesterone
Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …
FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder
Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …
The molecular relationship between stress and insomnia
JN Birch, WM Vanderheyden - Advanced Biology, 2022 - Wiley Online Library
The bi‐directional relationship between sleep and stress has been actively researched as
sleep disturbances and stress have become increasingly common in society. Interestingly …
sleep disturbances and stress have become increasingly common in society. Interestingly …
Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery
M Malekpour, D Shekouh, ME Safavinia… - Frontiers in …, 2023 - frontiersin.org
Stress-induced mental health disorders are affecting many people around the world.
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …
Analysis of the selective antagonist SAFit2 as a chemical probe for the FK506-binding protein 51
V Buffa, FH Knaup, T Heymann… - ACS Pharmacology & …, 2023 - ACS Publications
The FK506-binding protein 51 (FKBP51) has emerged as an important regulator of the
mammalian stress response and is involved in persistent pain states and metabolic …
mammalian stress response and is involved in persistent pain states and metabolic …
Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways
High levels of alcohol intake alter brain gene expression and can produce long-lasting
effects. FK506-binding protein 51 (FKBP51) encoded by Fkbp5 is a physical and cellular …
effects. FK506-binding protein 51 (FKBP51) encoded by Fkbp5 is a physical and cellular …
Dissociation between incubation of cocaine craving and anxiety-related behaviors after continuous and intermittent access self-administration
Studies using either continuous or intermittent access cocaine self-administration
procedures showed that cocaine seeking increases during abstinence (incubation of …
procedures showed that cocaine seeking increases during abstinence (incubation of …
[HTML][HTML] Genomic factors underlying sex differences in trauma-related disorders
OY Ponomareva, KJ Ressler - Neurobiology of stress, 2021 - Elsevier
Post-traumatic stress disorder (PTSD) is a devastating illness with treatment that is effective
in only approximately half of the population. This limited rate of response highlights the …
in only approximately half of the population. This limited rate of response highlights the …
The effects of sleep restriction during abstinence on oxycodone seeking: Sex-dependent moderating effects of behavioral and hypothalamic-pituitary-adrenal axis …
During opioid use and abstinence, sleep disturbances are common and are thought to
exacerbate drug craving. In this study, we tested the hypothesis that sleep restriction during …
exacerbate drug craving. In this study, we tested the hypothesis that sleep restriction during …