Allogeneic hematopoietic stem cell transplantation (SCT) is the sole established curative
treatment option for patients with sickle cell disease (SCD). However, a lack of HLA-identical …

Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi
anemia, glucose-6-phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The …

Introduction Hematopoietic stem cell transplant (HSCT) is the only readily available curative
option for sickle cell disease (SCD). Cure rates following human leukocyte antigen (HLA) …

Sickle cell disease (SCD) had first been mentioned in the literature a century ago.
Advancement in the molecular basis of the pathophysiology of the disease opens the door …

Background Gene therapy is an emerging treatment for sickle cell disease that works by
replacing a defective gene with a healthy gene, allowing the body to produce normal red …

The World Health Organization defines Quality of Life as an individual's perception of their
position in life in the context of the culture and values systems in which they live and in …

Allogenic hematopoietic cell transplantation (HCT) is the best curative approach for patients
with severe aplastic anemia (SAA). The outcomes of HCT from haploidentical family donors …

Hematopoietic stem cell transplantation (HSCT), also known as bone marrow
transplantation, has curative potential for various hematologic malignancies but is …

While exagamglogene autotemcel (Casgevy) and lovotibeglogene autotemcel (Lyfgenia)
have been approved by the US Food and Drug Administration (FDA) as the first cell-based …

Allogeneic hematopoietic cell transplantation, gene therapy, and gene editing offer a
potential cure for sickle cell disease (SCD). Unfortunately, myelodysplastic syndrome and …