Emerging and re-emerging warheads for targeted covalent inhibitors: applications in medicinal chemistry and chemical biology
M Gehringer, SA Laufer - Journal of medicinal chemistry, 2018 - ACS Publications
Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …
Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …
functions. Understanding the complexities of protein higher-order structures and dynamics …
Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation
O Koniev, A Wagner - Chemical Society Reviews, 2015 - pubs.rsc.org
Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …
development of biotherapeutics and chemical biology approaches. Recent endeavours in …
Recent advances in edible polymer based hydrogels as a sustainable alternative to conventional polymers
The over increasing demand of eco-friendly materials to counter various problems, such as
environmental issues, economics, sustainability, biodegradability, and biocompatibility …
environmental issues, economics, sustainability, biodegradability, and biocompatibility …
Modular diazo compound for the bioreversible late-stage modification of proteins
We introduce a versatile strategy for the bioreversible modification of proteins. Our strategy
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …
[图书][B] Biotransformations in organic chemistry: a textbook
K Faber, K Faber - 2011 - Springer
The use of natural catalysts-enzymes-for the transformation of nonnatural man-made
organic compounds is not at all new: they have been used for more than one hundred years …
organic compounds is not at all new: they have been used for more than one hundred years …
Resonance energy transfer: methods and applications
PG Wu, L Brand - Analytical biochemistry, 1994 - Elsevier
Resonance energy transfer is widely used in studies of biomolecular structure and
dynamics. It provides information about distances on the order of 10 to 100 Å and is thus …
dynamics. It provides information about distances on the order of 10 to 100 Å and is thus …
Dramatic aggregation of Alzheimer Aβ by Cu (II) is induced by conditions representing physiological acidosis
The cortical deposition of Aβ is an event that occurs in Alzheimer's disease, Down's
syndrome, head injury, and normal aging. Previously, in appraising the effects of different …
syndrome, head injury, and normal aging. Previously, in appraising the effects of different …
Stable-isotope dimethyl labeling for quantitative proteomics
In this paper, we report a novel, stable-isotope labeling strategy for quantitative proteomics
that uses a simple reagent, formaldehyde, to globally label the N-terminus and ε-amino …
that uses a simple reagent, formaldehyde, to globally label the N-terminus and ε-amino …
A brief survey of methods for preparing protein conjugates with dyes, haptens and crosslinking reagents
M Brinkley - Bioconjugate chemistry, 1992 - ACS Publications
Modification of proteins, DNA, and other biopolymers by labeling them with reporter
molecules has become a very powerful research tool in immunology, histochem-istry, and …
molecules has become a very powerful research tool in immunology, histochem-istry, and …