Regulation of ferroptosis by lipid metabolism
LE Pope, SJ Dixon - Trends in Cell Biology, 2023 - cell.com
Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …
The cell biology of ferroptosis
SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
Ferroptosis in immunostimulation and immunosuppression
Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
C Scarpellini, G Klejborowska, C Lanthier… - Trends in …, 2023 - cell.com
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA 1 s) are
considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA …
considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA …
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed
by caspase-3/7, which are dormant in living cells but become activated by upstream …
by caspase-3/7, which are dormant in living cells but become activated by upstream …
Discovery of novel potent covalent glutathione peroxidase 4 inhibitors as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer
T Chen, J Leng, J Tan, Y Zhao, S Xie… - Journal of Medicinal …, 2023 - ACS Publications
Glutathione peroxidase 4 (GPX4) is a promising target to induce ferroptosis for the treatment
of triple-negative breast cancer (TNBC). We designed and synthesized a novel series of …
of triple-negative breast cancer (TNBC). We designed and synthesized a novel series of …
Therapeutic inhibition of ferroptosis in neurodegenerative disease
Iron accumulation has been associated with the etiology and progression of multiple
neurodegenerative diseases (NDDs). The exact role of iron in these diseases is not fully …
neurodegenerative diseases (NDDs). The exact role of iron in these diseases is not fully …
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …
peroxidation. This process contributes to cellular and tissue damage in various human …