The accurate recognition of multiple sclerosis (MS) lesions is challenged by the high
sensitivity and imperfect specificity of MRI. To examine whether longitudinal changes in …

The proximity of immune cell aggregations to the vasculature is a hallmark of multiple
sclerosis. Furthermore, it is widely accepted that inflammation is able to modulate the …

The role of interferon-β as a disease-modifying drug (DMD) for the treatment of relapsing–
remitting multiple sclerosis (RRMS) is now well established, and its efficacy has been …

Objective: To determine the effect of interferon-β-1b (IFNβ-1b) treatment on total contrast-
enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in …

MION‐46L, a superparamagnetic iron oxide contrast agent, was investigated for its ability to
increase the sensitivity of in vivo 3D MRI in the detection of brain lesions in a chronic …

OBJECTIVE: To evaluate whether recombinant human interferon-beta-1a significantly
affects disease activity as measured by a reduction in the number and volume of Gd …

In vivo proton MRI was carried out on a 7 Tesla system at 2–3 day intervals over 10 days in
rats with adoptive transfer experimental allergic encephalomyelitis (AT-EAE), an animal …

The possibility of antagonizing tumor necrosis factor-α (TNF-α) in vivo with antibodies or
soluble TNF receptor has focused much interest on the role of this cytokine in the natural …

Abstract Background Gadopentate dimeglumine (Gd-DTPA) enhanced magnetic resonance
imaging (MRI) is widely applied for the visualization of blood brain barrier (BBB) breakdown …

Long TR and gadolinium enhanced spin echo brain MRI was performed weekly for three
months in three patients with relapsing-remitting or secondary progressive multiple …