Clinical biology of the pituitary adenoma
S Melmed, UB Kaiser, MB Lopes, J Bertherat… - Endocrine …, 2022 - academic.oup.com
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …
Pituitary-tumor endocrinopathies
S Melmed - New England Journal of Medicine, 2020 - Mass Medical Soc
Pituitary-Tumor Endocrinopathies Pituitary adenomas account for about 15% of intracranial
tumors. Clinical manifestations of disease reflect the oversecretion of the involved hormone …
tumors. Clinical manifestations of disease reflect the oversecretion of the involved hormone …
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Obesity is a risk factor for a wide variety of health problems. In a genome-wide association
study (GWAS) of body mass index (BMI) in Japanese people (n= 173,430), we found 85 loci …
study (GWAS) of body mass index (BMI) in Japanese people (n= 173,430), we found 85 loci …
Overview of the 2017 WHO classification of pituitary tumors
O Mete, MB Lopes - Endocrine pathology, 2017 - Springer
This review focuses on discussing the main changes on the upcoming fourth edition of the
WHO Classification of Tumors of the Pituitary Gland emphasizing histopathological and …
WHO Classification of Tumors of the Pituitary Gland emphasizing histopathological and …
Acromegaly: clinical features at diagnosis
L Vilar, CF Vilar, R Lyra, R Lyra, LA Naves - Pituitary, 2017 - Springer
Background Acromegaly is a rare and underdiagnosed disorder caused, in more than 95%
of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion …
of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion …
Short and tall stature: a new paradigm emerges
In the past, the growth hormone (GH)–insulin-like growth factor 1 (IGF-1) axis was often
considered to be the main system that regulated childhood growth and, therefore …
considered to be the main system that regulated childhood growth and, therefore …
Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
T Schöneberg, I Liebscher - Pharmacological reviews, 2021 - ASPET
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
Acromegaly
A Colao, LFS Grasso, A Giustina, S Melmed… - Nature Reviews …, 2019 - nature.com
Acromegaly is characterized by increased release of growth hormone and, consequently,
insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to …
insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to …
Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
Z Yang, JY Wang, F Yang, KK Zhu, GP Wang… - Nature Chemical …, 2024 - nature.com
GPR101 is an orphan G protein-coupled receptor actively participating in energy
homeostasis. Here we report the cryo-electron microscopy structure of GPR101 …
homeostasis. Here we report the cryo-electron microscopy structure of GPR101 …
Novel insights into pituitary tumorigenesis: genetic and epigenetic mechanisms
V Srirangam Nadhamuni, M Korbonits - Endocrine reviews, 2020 - academic.oup.com
Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …
Similar to many other endocrine tumors, over the last few years we have recognized the role …