ABSTRACT T-cells comprise many subtypes of specified lymphocytes, and their
differentiation and function take place in different tissues. This cellular diversity is also …

More than thirty years have passed since human T-cell leukemia virus type 1 (HTLV-1) was
described as the first retrovirus to be the causative agent of a human cancer, adult T-cell …

Introduction Germline CARD11 gain-of-function (GOF) mutations cause B cell Expansion
with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations …

Global dysregulation of microRNAs (miRNAs), a class of non-coding RNAs that regulate
genes expression, is a common feature of human tumors. Profiling of cellular miRNAs on …

Genomic analysis of cancer offers the hope of identifying new treatments or aiding in the
selection of existing treatments. Rare leukemias pose additional challenges in this regard as …

Abstract Introduction Adult T‐Cell Leukemia/Lymphoma (ATLL) is an aggressive T‐cell
malignancy without known characteristic cytogenetic abnormalities. Recurrent mutations in …

Peripheral T-cell lymphomas (PTCL) are rare lymphoproliferative disorders with poor
outcomes and high rates of relapse. Incidence varies although the most common subtypes …

Cutaneous lymphomas encompass a heterogeneous group of neoplasms with a wide
spectrum of clinical presentations, histopathologic features, and prognosis. Because there …

T‐cell prolymphocytic leukemia (T‐PLL) is a rare T‐cell leukemia characterized in many
patients by marked peripheral lymphocytosis, prominent splenomegaly, and skin lesions …

Adult cell lymphoma/leukemia (ATLL) is a type of lymphoma consisting of T-cells that are
related to infection with the human T lymphotropic virus (HTLV-1). Four clinical forms have …