Interactions between hypoxic and hypercapnic signaling pathways, expressed as ventilatory
changes occurring during and following a simultaneous hypoxic-hypercapnic gas challenge …

Oxygen (O2) is essential for life and therefore the supply of sufficient O2 to the tissues is a
major physiological challenge. In mammals, a deficit of O2 (hypoxia) triggers rapid …

The oxygen transport cascade describes the physiological steps that bring atmospheric
oxygen into the body where it is delivered and consumed by metabolically active tissue. As …

Advances in our understanding of brain mechanisms for the hypoxic ventilatory response,
coordinated changes in blood pressure, and the long-term consequences of chronic …

BACKGROUND AND PURPOSE: Decreased oxygen supply may cause neuronal damage
in the brains of patients with COPD, which is manifested by clinical symptoms such as …

The cardioaccelerator and ventilatory responses to rhythmic exercise in the human are
commonly viewed as being mediated predominantly via feedforward 'central command' …

Rett syndrome is a neurodevelopmental disorder caused by mutations in methyl-CpG-
binding protein 2 (MECP2), a transcriptional regulator. In addition to cognitive …

OBJECTIVE Nocturnal periodic breathing occurs more frequently in men than in women with
various clinical and pathophysiologic conditions. The mechanisms accounting for this sex …

Damaraland mole-rats (Fukomys damarensis) are a hypoxia-tolerant fossorial species that
exhibit a robust hypoxic metabolic response (HMR) and blunted hypoxic ventilatory …

The pulmonary system is the first and last “line of defense” in terms of maintaining blood gas
homeostasis during exercise. Our review provides the reader with an overview of how the …