Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Recent experimental evidence suggests that transcellular propagation of fibrillar protein
aggregates drives the progression of neurodegenerative diseases in a prion-like manner …

Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a
large number of extracellular ligands. Members of both cell surface heparan sulfate …

▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

Covering: up to August 2001This review covers the structure and function of heparin and
heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including …

The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Macroscale drug delivery (MDD) devices are engineered to exert spatiotemporal control
over the presentation of a wide range of bioactive agents, including small molecules …

As their name implies, MMPs were first described as proteases that degrade extracellular
matrix proteins, such as collagens, elastin, proteoglycans, and laminins. However, studies of …