Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Membrane-associated progesterone receptors (MAPR) are a group of four rather small,
partially homologous proteins, which share a similar non-covalent heme-binding domain …

Background Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding
protein inducing dimerization with cytochrome P450, which mediates chemoresistance …

CRISPR/Cas gene studies were conducted in HeLa cells where either PGRMC1, TMEM97
or both proteins were removed via gene editing. A series of radioligand binding studies …

Introduction Amyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ
protein and are hypothesized to cause synaptotoxicity and memory failure as they build up …

Background Increased expression of the progesterone receptor membrane component 1
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …

There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease
characterized by polycystic ovaries, hyperandrogenism and anovulation. It is one of the main …

Detrimental dietary habits with high-fat food are common in the psychiatric population,
leading to higher obesity rate. Olanzapine (OLZ), as one of the mainstream antipsychotic …