The epigenome is a dynamic system of chemical modifications that operate to control
chromatin structure and regulate gene activity without altering the underlying DNA …

Objective. Osteoarthritis (OA) is a complex disease involving contributions from both local
joint tissues and systemic sources. Patient characteristics, encompassing sociodemographic …

Abstract Changes in bone architecture and metabolism with aging increase the likelihood of
osteoporosis and fracture. Age‐onset osteoporosis is multifactorial, with contributory …

El hueso es un tejido que se encuentra en un constante proceso de remodelado debido a la
acción de los osteoblastos, encargados de la formación ósea, y de los osteoclastos …

The hallmark of osteoarthritis (OA) is the progressive degeneration of articular cartilage,
although bone and synovia are also involved in the development of the disease [1] …

Osteoporosis is a common, aging-related disease diagnosed primarily by measuring bone
mineral density (BMD). We performed two genome-wide association studies (GWAS) to …

Osteoporosis is a prevalent disease that typically reduces bone strength and predisposes to
fractures. It is a multifactorial disorder resulting from the interaction of genetic and acquired …

Most rheumatic diseases are complex or multifactorial entities with pathogeneses that
interact with both multiple genetic factors and a high number of diverse environmental …

Disparities exist in fracture incidence, prevalence, rates and risk factors between social and
ethnic groups. Whilst genetic predisposition, such as sex and ethnicity, influence the risk of …

Osteoporoz (OP), düşük kemik kütlesi ve kemik dokusunun mikromimarisinin bozulması,
bunun sonucunda kemik kırılganlığında ve kırılma eğiliminde artış ile karakterize sistemik bir …