Objective Osteoarthritis (OA) affects humans and several other animals. Thus, the
mechanisms underlying this disorder, such as specific skeletal tissue DNA methylation …

Osteoporosis (OP) commonly occurs in the setting of inflammatory arthritis, whereas there is
an inverse relationship with osteoarthritis (OA). We review the recent updates in …

Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8
monozygotic twin pairs with IS, 6 discordant (Cobb angle difference> 10°) and 2 concordant …

Objectives Epigenetic mechanisms influence the development and maintenance of complex
phenotypes and may also contribute to the evolution of species–specific phenotypes. With …

The bone repair and substitute have been developed for decades with the bone defect
repair applied successfully in clinical. However, implant complications may occur in more …

Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …

Introduction Although there is a documented social gradient for osteoporosis, the underlying
mechanism (s) for that gradient remain unknown. We propose a conceptual model based …

Abstract Purpose of Review Epigenetic mechanisms modify gene activity in a stable manner
without altering DNA sequence. They participate in the adaptation to the environment, as …

Methods A Medline search was performed in March of 2013 to identify relevant genetic
studies of OCD in all animals and humans (Fig. 1). Searches were performed for both …

The skeleton is a metabolically active organ throughout life where specific bone cell activity
and paracrine/endocrine factors regulate its morphogenesis and remodeling. In recent …