A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …

Epigenetic mechanisms are able to alter gene expression, without altering DNA sequence,
in a stable manner through cell divisions. They include, among others, the methylation of …

OBJECTIVE: Osteoarthritis is the most prevalent joint disease worldwide and the primary
cause of musculoskeletal dysfunction. Epigenetic changes in various genes, particularly …

The data explosion in the last decade is revolutionizing diagnostics research and the
healthcare industry, offering both opportunities and challenges. These high-throughput …

Background: Osteoporosis is a common degenerative bone disease which is characterized
with decreased bone strength and increased risk of fracture. The abnormal bone metabolism …

Interactions between genetic and environmental factors in migraine are well known and can
potentially determine an individual's susceptibility to disease and responsiveness to …

Malnutrition in early life increases the risk of osteoporosis, but the association of early-life
undernutrition combined with adulthood obesity patterns with low-energy fracture remains …

Objective To determine genome-wide DNA methylation profiles of knee cartilage from
patients with Kashin-Beck disease (KBD) and osteoarthritis (OA). Method Knee cartilage …

The aim of this study was to investigate the relationship between osteoporosis and
osteoarthritis by analyzing the DNA methylation in osteoporosis and osteoarthritis. The …

Epigenetic factors, such as DNA methylation, play an influential role in the development of
the degenerative joint disease osteoarthritis (OA). These molecular mechanisms have been …