Dopamine has been implicated in value-based learning and decision making by signaling
reward prediction errors and facilitating cognitive flexibility, incentive motivation, and …

High impulsivity, mediated through ventral striatal dopamine signalling, represents an
established risk factor for substance abuse, and may likewise confer vulnerability to …

Amotivational states and insufficient recruitment of mental effort have been observed in a
variety of clinical populations, including depression, traumatic brain injury, post-traumatic …

Cognitive accounts of gambling suggest that the experience of almost winning—so-called
'near-misses'—encourage continued play and accelerate the development of pathological …

Drug addiction is a compulsive behavioral abnormality. In spite of pharmacological
treatments and psychosocial support to reduce or eliminate drug intake, addiction tends to …

This study investigated the dynamics of dopamine receptor desensitization and
internalization, thereby proposing a new technique for non-invasive, in vivo measurements …

Neuromodulators such as dopamine can alter the intrinsic firing properties of neurons and
may thereby change the configuration of larger functional circuits. The primate orbitofrontal …

Rationale Impulsivity is a key symptom of attention-deficit hyperactivity disorder (ADHD). The
use of the norepinephrine reuptake inhibitor, atomoxetine, to treat ADHD suggests that the …

Individual differences in dopamine (DA) signaling, including low striatal D2/3 receptors, may
increase vulnerability to substance abuse, although whether this phenotype confers …

Immaturities in adolescent reward processing are thought to contribute to poor decision
making and increased susceptibility to develop addictive and psychiatric disorders. Very …