Chemogenetic activation of midbrain dopamine neurons affects attention, but not impulsivity, in the five-choice serial reaction time task in rats
L Boekhoudt, ES Voets… - …, 2017 - nature.com
Attentional impairments and exaggerated impulsivity are key features of psychiatric
disorders, such as attention-deficit/hyperactivity disorder, schizophrenia, and addiction …
disorders, such as attention-deficit/hyperactivity disorder, schizophrenia, and addiction …
Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats
Background: Impulsivity is understood as a range of behaviours, but the association
between these behaviours is not well understood. Although high motor impulsivity is a key …
between these behaviours is not well understood. Although high motor impulsivity is a key …
Frontal traumatic brain injury in rats causes long-lasting impairments in impulse control that are differentially sensitive to pharmacotherapeutics and associated with …
C Vonder Haar, FCW Lam, WK Adams… - ACS chemical …, 2016 - ACS Publications
Traumatic brain injury (TBI) affects millions yearly, and is increasingly associated with
chronic neuropsychiatric symptoms. We assessed the long-term effects of different bilateral …
chronic neuropsychiatric symptoms. We assessed the long-term effects of different bilateral …
Chemogenetic inhibition of dopaminergic projections to the nucleus accumbens has sexually dimorphic effects in the rat gambling task.
TJ Hynes, JMM Ferland, TL Feng… - Behavioral …, 2020 - psycnet.apa.org
Women and men can differ in their propensity to take risks and develop impulse control and
addiction disorders. Sexual dimorphisms in behavioral control by the mesolimbic …
addiction disorders. Sexual dimorphisms in behavioral control by the mesolimbic …
Seizurogenic effect of perfluorooctane sulfonate in zebrafish larvae
While the developmental neurotoxicity of perfluorooctane sulfonate (PFOS) has been
reported, its seizurogenic potential has not been investigated. Behavior assessment was …
reported, its seizurogenic potential has not been investigated. Behavior assessment was …
[HTML][HTML] Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D1-and D2-like receptors in a rat model of …
L Bellés, C Arrondeau, G Urueña-Méndez… - Pharmacology …, 2023 - Elsevier
Impulsivity is a multidimensional construct, but the relationships between its constructs and
their respective underlying dopaminergic underpinnings in the general population remain …
their respective underlying dopaminergic underpinnings in the general population remain …
Assessing attention and impulsivity in the variable stimulus duration and variable intertrial interval rodent continuous performance test schedules using noradrenaline …
L Klem, MM Nielsen, SB Gestsdóttir, SL Frandsen… - …, 2023 - Springer
Rationale Noradrenergic dysfunction is associated with disorders of impulsivity and
inattention. The rodent continuous performance test (rCPT) quantifies changes in attention …
inattention. The rodent continuous performance test (rCPT) quantifies changes in attention …
Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex
DJ Noble, A Mohammadkhani, M Qiao… - European Journal of …, 2024 - Wiley Online Library
The orbitofrontal cortex (OFC) is a key node in the cortico‐limbic‐striatal circuitry that
influences decision‐making guided by the relative value of outcomes. Midbrain dopamine …
influences decision‐making guided by the relative value of outcomes. Midbrain dopamine …
GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization
RA Rifkin, D Huyghe, X Li, M Parakala… - Proceedings of the …, 2018 - National Acad Sciences
GABABR-dependent activation of G protein-gated inwardly rectifying potassium channels
(GIRK or KIR3) provides a well-known source of inhibition in the brain, but the details on …
(GIRK or KIR3) provides a well-known source of inhibition in the brain, but the details on …
[HTML][HTML] Orbitofrontal lesion alters brain dynamics of emotion-attention and emotion-cognitive control interaction in humans
V Kuusinen, E Cesnaite, J Peräkylä… - Frontiers in Human …, 2018 - frontiersin.org
Patients with lesion to the orbitofrontal cortex (OFC) experience challenges in emotional
control and emotion-guided behaviors. The OFC is known to participate in executive …
control and emotion-guided behaviors. The OFC is known to participate in executive …