Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

Currently, the number of new cancer cases and deaths worldwide is increasing year on
year. In addition to the requirement for cancer prevention, the top priority is still to seek the …

The drug resistance and low specificity of current available chemotherapeutics to cancer
cells are the main reasons responsible for the failure of cancer chemotherapy and remain …

Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

The development of effective antibacterial agents equipped with novel action modes and
unique skeletons starting from natural compounds serves as an important strategy in the …

Naturally occurring indole alkaloids are ubiquitously present in nature and possess
extensive biological properties and structural diversity. Mechanistically, naturally occurring …

A cascade aldimine condensation/1, 6-hydride transfer/Mannich-type cyclization of indole-
derived phenylenediamine with aldehydes was developed for one-step construction of a …

Cancer is the leading cause of mortality all over the world. Scientific investigation has
demonstrated that disruptions in the process of autophagy are frequently interrelated with …

A [6+ 1] annulation reaction via cascade 1, 6-hydride transfer/cyclization is reported to
construct a polycyclic 3, 4-fused azepinoindole skeleton. The newly designed 4-amino …