Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …

Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Abstract Rationale Circular RNAs (circRNAs) have been demonstrated to contribute to
esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be …

Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within
tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of …

Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat
approximately 50% of all cancer patients either alone or in combination with other treatment …