The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …

Individual cell heterogeneity within a population can be critical to its peculiar function and
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …

The development of new drugs is multidisciplinary and systematic work. High-throughput
techniques based on “-omics” have driven the discovery of biomarkers in diseases and …

Circulating tumor cells are tumor cells with high vitality and high metastatic potential that
invade and shed into the peripheral blood from primary solid tumors or metastatic foci. Due …

The identification of extensive genetic heterogeneity in human breast carcinomas poses a
significant challenge for designing effective treatment regimens. Significant genomic …

Abstract Treatment of cancer metastasis has been largely ineffective. It is paramount to
understand the mechanisms underlying the metastatic process, of which the tumor …

Data normalization is vital to single-cell sequencing, addressing limitations presented by low
input material and various forms of bias or noise present in the sequencing process. Several …

Breast cancer is the second most frequent cancer in the world. It is a heterogeneous disease
and the leading cause of cancer mortality in women. Advances in molecular technologies …

The hallmarks of cancer were proposed as a logical framework to guide research efforts that
aim to understand the molecular mechanisms and derive treatments for this highly complex …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …