This review provides a detailed discussion of recent advances in the medicinal chemistry of
camptothecin, a potent antitumor antibiotic. Two camptothecin analogues are presently …

Abstract Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds
that bind to the minor groove of double-stranded DNA in a sequence-specific manner …

Homocamptothecins (hCPTs) represent a new generation of antitumor agents targeting DNA
topoisomerase I. The expanded seven-membered lactone E-ring that characterizes hCPTs …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

Phenotype-based screening has been recognized as a key approach to the discovery of
novel therapeutic agents because of the recent withdrawal of marketed drugs developed by …

DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic
modification involved in gene regulation. Families of conjugates of procainamide, an …

Silica/titania hollow nanoparticles (HNPs) with 50 nm were fabricated by using the
dissolution and redeposition method and modified with anti‐[human epidermal growth factor …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Regions of double-stranded (duplex) DNA with purine bases predominantly in one strand
and pyrimidine bases in the other may bind oligonucleotides of an appropriate sequence to …

A series of 4 functionalized head-to-head-linked hairpin oligo (N-methylpyrrole)
carboxamides with different linkers have been synthesized. Their ability to bind double …