Development of novel pyrazole, imidazo [1, 2-b] pyrazole, and pyrazolo [1, 5-a] pyrimidine derivatives as a new class of COX-2 inhibitors with immunomodulatory …
Searching for new compounds with anti-inflammatory properties is a significant target since
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …
Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with …
Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives as a new class of EGFR Wt and VEGFR-2 inhibitors with apoptotic …
RR Raslan, YA Ammar, SA Fouad, SA Hessein… - RSC …, 2023 - pubs.rsc.org
Developing new agents for cancer treatment remains a top priority because it is one of the
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
A novel of quinoxaline derivatives tagged with pyrrolidinyl scaffold as a new class of antimicrobial agents: Design, synthesis, antimicrobial activity, and molecular …
MM Abdelgalil, YA Ammar, GAME Ali, AK Ali… - Journal of Molecular …, 2023 - Elsevier
Globally, infectious diseases are becoming harder to treat due to antibiotic resistance, which
has reached high levels. Additionally, developing new therapeutic options to combat the …
has reached high levels. Additionally, developing new therapeutic options to combat the …
A new class of anti-proliferative activity and apoptotic inducer with molecular docking studies for a novel of 1, 3-dithiolo [4, 5-b] quinoxaline derivatives hybrid with a …
MA Ismail, MS Abusaif, MSA El-Gaby, YA Ammar… - RSC …, 2023 - pubs.rsc.org
A new series of 6-(pyrrolidin-1-ylsulfonyl)-[1, 3] dithiolo [4, 5-b] quinoxaline-2-ylidines 10a–f,
12, 14, 16, and 18 were designed, synthesized, and evaluated for their in vitro anticancer …
12, 14, 16, and 18 were designed, synthesized, and evaluated for their in vitro anticancer …
Development of new spiro [1, 3] dithiine-4, 11′-indeno [1, 2-b] quinoxaline derivatives as S. aureus Sortase A inhibitors and radiosterilization with molecular …
Multi-drug resistant microbes have become a severe threat to human health and arise a
worldwide concern. A total of fifteen spiro-1, 3-dithiinoindenoquinoxaline derivatives 2–7 …
worldwide concern. A total of fifteen spiro-1, 3-dithiinoindenoquinoxaline derivatives 2–7 …
Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives as Carbonic Anhydrase I and II Inhibitors: Design …
A Ragab, SA Fouad, YA Ammar, DS Aboul-Magd… - Antibiotics, 2023 - mdpi.com
Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
In vitro biological studies and computational prediction-based analyses of pyrazolo [1, 5-a] pyrimidine derivatives
AA Almehizia, WM Aboulthana, AM Naglah… - RSC …, 2024 - pubs.rsc.org
There is a need for new pharmaceutical discoveries from bioactive nitrogenous derivatives
due to the emergence of scourges, numerous pandemics, and diverse health problems. In …
due to the emergence of scourges, numerous pandemics, and diverse health problems. In …
Development of pyrazolo[1,5-a]pyrimidine-based antibacterial agents
AEM Mekky, NAS Taha, NG Mohammed… - Synthetic …, 2023 - Taylor & Francis
In the present study, a facile method was adopted to efficiently prepare new pyrazolo [1, 5-a]
pyrimidin-2-amines linked to arene units in good to excellent yields. A mixture of …
pyrimidin-2-amines linked to arene units in good to excellent yields. A mixture of …