Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease

R Iturriaga, R Del Rio, J Idiaquez, VK Somers - Biological research, 2016 - Springer
The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO 2,
PCO 2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory …

Carotid body ablation abrogates hypertension and autonomic alterations induced by intermittent hypoxia in rats

R Del Rio, DC Andrade, C Lucero, P Arias… - Hypertension, 2016 - Am Heart Assoc
Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, enhances
carotid body (CB) chemosensory responses to hypoxia and produces autonomic …

Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link

R Del Rio, EA Moya, R Iturriaga - European Respiratory Journal, 2010 - Eur Respiratory Soc
Intermittent hypoxia, a feature of obstructive sleep apnoea, potentiates ventilatory hypoxic
responses, alters heart rate variability and produces hypertension, partially owing to an …

[PDF][PDF] Heart rate variability as a method for assessment of the autonomic nervous system and the adaptations to different physiological and pathological conditions

ZZ Taralov, KV Terziyski, SS Kostianev - Folia medica, 2015 - archive.sciendo.com
The autonomic nervous system controls the smooth muscles of the internal organs, the
cardiovascular system and the secretory function of the glands and plays a major role in the …

Translating carotid body function into clinical medicine

R Iturriaga - The Journal of physiology, 2018 - Wiley Online Library
The carotid body (CB) is considered the main O2 chemoreceptor, which contributes to
cardiorespiratory homeostasis and ventilatory acclimatization. In clinical medicine, the most …

Increased cardio-respiratory coupling evoked by slow deep breathing can persist in normal humans

TE Dick, JR Mims, YH Hsieh, KF Morris… - Respiratory physiology & …, 2014 - Elsevier
Slow deep breathing (SDB) has a therapeutic effect on autonomic tone. Our previous studies
suggested that coupling of the cardiovascular to the respiratory system mediates plasticity …

Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia

R Del Rio, EA Moya, R Iturriaga - Brain research, 2011 - Elsevier
The enhanced carotid body (CB) chemosensory response to hypoxia induced by chronic
intermittent hypoxia (CIH) has been attributed to oxidative stress, which is expected to …

Carotid body potentiation induced by intermittent hypoxia: implications for cardiorespiratory changes induced by sleep apnoea

R Iturriaga, EA Moya, R Del Rio - Clinical and Experimental …, 2009 - Wiley Online Library
Summary 1 The most usual form of chronic hypoxia in humans is the intermittent hypoxia
resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent …

Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia

R Iturriaga, DC Andrade, R Del Rio - Frontiers in physiology, 2014 - frontiersin.org
The carotid body (CB) plays a main role in the maintenance of the oxygen homeostasis. The
hypoxic stimulation of the CB increases the chemosensory discharge, which in turn elicits …