Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms

R Butowt, K Bilinska, CS von Bartheld - Trends in Neurosciences, 2023 - cell.com
The mechanisms of olfactory dysfunction in COVID-19 are still unclear. In this review, we
examine potential mechanisms that may explain why the sense of smell is lost or altered …

Prevalence of olfactory dysfunction with the omicron variant of SARS-CoV-2: a systematic review and meta-analysis

CS von Bartheld, L Wang - Cells, 2023 - mdpi.com
The omicron variant is thought to cause less olfactory dysfunction than previous variants of
SARS-CoV-2, but the reported prevalence differs greatly between populations and studies …

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection

D Xu, W Jiang, L Wu, RG Gaudet, ES Park, M Su… - Nature, 2023 - nature.com
Understanding protective immunity to COVID-19 facilitates preparedness for future
pandemics and combats new SARS-CoV-2 variants emerging in the human population …

Viral membrane fusion: a dance between proteins and lipids

JM White, AE Ward, L Odongo… - Annual review of …, 2023 - annualreviews.org
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …

[HTML][HTML] Host cell-intrinsic innate immune recognition of SARS-CoV-2

EA Madden, MS Diamond - Current opinion in virology, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of
2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical …

Application of machine learning on understanding biomolecule interactions in cellular machinery

R Dixit, K Khambhati, KV Supraja, V Singh… - Bioresource …, 2023 - Elsevier
Abstract Machine learning (ML) applications have become ubiquitous in all fields of
research including protein science and engineering. Apart from protein structure and …

Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice

AD Kenney, A Zani, J Kawahara, AC Eddy, XL Wang… - EMBO …, 2023 - embopress.org
Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein that alters cell
membranes to block fusion of viruses. Conflicting reports identified opposing effects of …

IFITM protein regulation and functions: Far beyond the fight against viruses

N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …

Host membranes as drivers of virus evolution

M Matveeva, M Lefebvre, H Chahinian, N Yahi… - Viruses, 2023 - mdpi.com
The molecular mechanisms controlling the adaptation of viruses to host cells are generally
poorly documented. An essential issue to resolve is whether host membranes, and …

Post-translational modifications of cGAS-STING: A critical switch for immune regulation

Y Yu, J Liu, C Liu, R Liu, L Liu, Z Yu, J Zhuang, C Sun - Cells, 2022 - mdpi.com
Innate immune mechanisms initiate immune responses via pattern-recognition receptors
(PRRs). Cyclic GMP-AMP synthase (cGAS), a member of the PRRs, senses diverse …