Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …

BACKGROUND Cryopreservation has been extensively used in assisted reproductive
technology, agriculture and conservation programmes for endangered species. The …

Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

Chronic sun exposure causes photoaging of human skin, a process that is characterized by
clinical, histological and biochemical changes which differ from alterations in chronologically …

Mutations of mitochondrial (mt) DNA accumulate during normal aging. The most frequent
mutation is a 4,977-base pair deletion also called the common deletion, which is increased …

In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells
(iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH+ …

Respiratory function of mitochondria is compromised in aging human tissues and severely
impaired in the patients with mitochondrial disease. A wide spectrum of mitochondrial DNA …

Mutations of mitochondrial (mt) DNA such as the 4977 base-pair large-scale deletion, also
called common deletion, are increased in photoaged skin. Direct evidence for their induction …

Gulf War illness (GWI) is an important exemplar of environmentally-triggered chronic
multisymptom illness, and a potential model for accelerated aging. Inflammation is the main …

Mitochondria produce metabolic energy, serve as biosensors for oxidative stress, and
eventually become effector organelles for cell death through apoptosis. The extent to which …