The physiological mechanisms of the sex-based difference in outcomes of COVID19 infection

S Wray, S Arrowsmith - Frontiers in Physiology, 2021 - frontiersin.org
The scale of the SARS-CoV-2 pandemic has thrust a spotlight on the sex-based differences
in response to viral diseases; morbidity and mortality are greater in men than women. We …

Diagnostic value of D-dimer in COVID-19: a meta-analysis and meta-regression

H Zhan, H Chen, C Liu, L Cheng… - Clinical and Applied …, 2021 - journals.sagepub.com
The prognostic role of hypercoagulability in COVID-19 patients is ambiguous. D-dimer, may
be regarded as a global marker of hemostasis activation in COVID-19. Our study was to …

Does genetic predisposition contribute to the exacerbation of COVID-19 symptoms in individuals with comorbidities and explain the huge mortality disparity between …

N Yamamoto, R Yamamoto, Y Ariumi… - International Journal of …, 2021 - mdpi.com
The elderly and patients with several comorbidities experience more severe cases of
coronavirus disease 2019 (COVID-19) than healthy patients without underlying medical …

Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients

JR Lechien, CM Chiesa-Estomba, LA Vaira… - European Archives of …, 2021 - Springer
Objective To investigate prevalence and epidemiological and clinical factors associated with
olfactory dysfunction (OD) and gustatory dysfunction (GD) in COVID-19 patients according to …

Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age

J O'Brien, KY Du, C Peng - Journal of ovarian research, 2020 - Springer
Male sex and older age have been reported to be associated with worse outcomes from
COVID-19. It was postulated that estrogens may play a role in reducing the severity of the …

ACE2, COVID-19 infection, inflammation, and coagulopathy: missing pieces in the puzzle

Z Abassi, AAR Higazi, S Kinaneh, Z Armaly… - Frontiers in …, 2020 - frontiersin.org
Engulfed by the grave consequences of the coronavirus disease 2019 (COVID-19)
pandemic, a better understanding of the unique pattern of viral invasion and virulence is of …

Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19

R Maeda, N Seki, Y Uwamino, M Wakui… - Nature …, 2023 - nature.com
Effective early-stage markers for predicting which patients are at risk of developing SARS-
CoV-2 infection have not been fully investigated. Here, we performed comprehensive serum …

Saliva microbiome in relation to SARS-CoV-2 infection in a prospective cohort of healthy US adults

AJS Armstrong, DB Horton, T Andrews, P Greenberg… - …, 2023 - thelancet.com
Background The clinical outcomes of SARS-CoV-2 infection vary in severity, potentially
influenced by the resident human microbiota. There is limited consensus on conserved …

[HTML][HTML] Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia

M Camici, P Zuppi, P Lorenzini, L Scarnecchia… - International Journal of …, 2021 - Elsevier
Objectives To investigate the association between sex hormones and the severity of
coronavirus disease 2019 (COVID-19). Furthermore, associations between sex hormones …

Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19

DC Sarver, GW Wong - Biochemical and biophysical research …, 2021 - Elsevier
Obesity is a major risk factor for SARS-CoV-2 infection and COVID-19 severity. The
underlying basis of this association is likely complex in nature. The host-cell receptor …