Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer's disease
X Wang, X Zhang, J Liu, J Zhang, C Liu, Y Cui… - Alzheimer's Research & …, 2024 - Springer
Background Previous studies have demonstrated that early intervention was the best plan to
inhibit the progression of Alzheimer's disease (AD), which relied on the discovery of early …
inhibit the progression of Alzheimer's disease (AD), which relied on the discovery of early …
Relationship between reactive astrocytes, by [18F] SMBT-1 imaging, with amyloid-beta, tau, glucose metabolism, and microgliosis in mouse models of Alzheimer′ s …
Purpose Reactive astrocytes play an important role in the development of Alzheimer′ s
disease (AD). Here, we aim to investigate the temporospatial relationship between reactive …
disease (AD). Here, we aim to investigate the temporospatial relationship between reactive …
Insights to develop taudirected therapeutics to protect the synaptic integrity for tauopathies
E Cha, HJ Kim, SM Lim - Bulletin of the Korean Chemical …, 2024 - Wiley Online Library
Tauopathy is characterized by the abnormal aggregation of tau proteins. In order to develop
drugs for tauopathies, a variety of different therapeutic strategies have been investigated …
drugs for tauopathies, a variety of different therapeutic strategies have been investigated …
[HTML][HTML] In vivo reactive astrocyte imaging using [18F] SMBT-1 in tauopathy and familial Alzheimer's disease mouse models: A multi-tracer study
Y Kong, L Cao, J Wang, J Zhuang, F Xie, C Zuo… - Journal of the …, 2024 - Elsevier
Background Reactive astrocytes play an important role in the development of Alzheimer's
disease and primary tauopathies. Here, we aimed to investigate the relationships between …
disease and primary tauopathies. Here, we aimed to investigate the relationships between …
Tau 相关神经退行性疾病的治疗: 靶向分子, 突触和细胞
M Robbins - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
Advances in experimental and computational technologies continue to grow rapidly to
provide novel avenues for the treatment of neurodegenerative disorders. Despite this, there …
provide novel avenues for the treatment of neurodegenerative disorders. Despite this, there …
Hippocampal mGluR5 levels are comparable in Alzheimer′ s and control brains, and divergently influenced by amyloid and tau in control brain
J Wang, S Savodalli, Y Kong, C Mashio, U Konietzko… - bioRxiv, 2024 - biorxiv.org
Background: Metabotropic glutamate receptor 5 (mGluR5) modulates excitatory
glutamatergic synaptic transmission and plays an important role in learning and memory …
glutamatergic synaptic transmission and plays an important role in learning and memory …
Increased regional P2X7R expression detected by [18F] GSK1482160 PET in a tauopathy mouse model
Y Kong, L Cao, J Wang, J Zhuang, Y Liu, L Bi, Y Qiu… - bioRxiv, 2024 - biorxiv.org
Neuroinflammation plays an important role in Alzheimers disease and primary tauopathies.
The aim of the current study was to map [18F] GSK1482160 for imaging of purinergic P2X7R …
The aim of the current study was to map [18F] GSK1482160 for imaging of purinergic P2X7R …
Positron emission tomography in animal models of Alzheimer's disease amyloidosis
R Ni - 2021 - preprints.org
Animal models of Alzheimer's disease amyloidosis that recapitulate cerebral amyloid-beta
pathology have been widely used in preclinical research, and have greatly enabled the …
pathology have been widely used in preclinical research, and have greatly enabled the …
[PDF][PDF] INVESTIGATING ASSOCIATIONS BETWEEN ELECTROPHYSIOLOGICAL AND PATHOLOGICAL CHANGES IN THE TgF344-AD RAT MODEL FOR …
Y Sun - 2023 - core.ac.uk
The hippocampal formation is crucial for encoding and retrieving declarative memory. This
includes episodic memory, which represents personal experiences or places and …
includes episodic memory, which represents personal experiences or places and …