Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

The actin cytoskeleton plays a crucial role in many cellular processes while its
reorganization is important in maintaining cell homeostasis. However, in the case of cancer …

Neutrophil extracellular traps (NETs) are webs of extracellular nuclear DNA extruded by
dying neutrophils infiltrating tissue. NETs constitute a defence mechanism to entrap and kill …

Purpose: Here, we have investigated treatment resistance mechanisms in small cell lung
cancer (SCLC) by focusing on comparing the genotype and phenotype in tumor samples of …

Epigenetic regulation plays an important role in the occurrence, development and treatment
of malignant tumors; and a great deal of attention has been paid to the histone methylation …

Despite the rapid advancement in the introduction of new drugs for cancer therapy, the
frequent emergence of drug resistance leads to disease progression or tumor recurrence …

In recent years, natural products have increasingly attracted more attention because of their
potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a …

Low-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR
protein family, which includes several structurally homologous cell surface receptors with a …

Abstract SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently
linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer …

A number of novel anticancer drugs have been developed in recent years. However, the
mortality of cancer patients remains high because of the emergence of drug resistance. It …