New perspectives in diabetic neuropathy
Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …
Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
B Kim, EL Feldman - Experimental & molecular medicine, 2015 - nature.com
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity,
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …
Altered extracellular vesicle concentration, cargo, and function in diabetes
Type 2 diabetes is a chronic age-associated degenerative metabolic disease that reflects
relative insulin deficiency and resistance. Extracellular vesicles (EVs)(exosomes …
relative insulin deficiency and resistance. Extracellular vesicles (EVs)(exosomes …
A brief overview of tauopathy: causes, consequences, and therapeutic strategies
There are currently no disease-modifying therapies for the treatment of tauopathies, a group
of progressive neurodegenerative disorders that are pathologically defined by the presence …
of progressive neurodegenerative disorders that are pathologically defined by the presence …
Diabetic neuropathy: cellular mechanisms as therapeutic targets
AM Vincent, BC Callaghan, AL Smith… - Nature Reviews …, 2011 - nature.com
In patients with diabetes, nerve injury is a common complication that leads to chronic pain,
numbness and substantial loss of quality of life. Good glycemic control can decrease the …
numbness and substantial loss of quality of life. Good glycemic control can decrease the …
The role of type 2 diabetes in neurodegeneration
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
Insulin resistance in the nervous system
B Kim, EL Feldman - Trends in Endocrinology & Metabolism, 2012 - cell.com
Metabolic syndrome is a cluster of cardiovascular risk factors including obesity, diabetes and
dyslipidemia. Insulin resistance (IR) is at the core of metabolic syndrome. In adipose tissue …
dyslipidemia. Insulin resistance (IR) is at the core of metabolic syndrome. In adipose tissue …
Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease
M Yarchoan, SE Arnold - Diabetes, 2014 - Am Diabetes Assoc
A growing body of clinical and epidemiological research suggests that two of the most
common diseases of aging, type 2 diabetes (T2DM) and Alzheimer disease (AD), are linked …
common diseases of aging, type 2 diabetes (T2DM) and Alzheimer disease (AD), are linked …
GluT4: A central player in hippocampal memory and brain insulin resistance
EC McNay, J Pearson-Leary - Experimental neurology, 2020 - Elsevier
Insulin is now well-established as playing multiple roles within the brain, and specifically as
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …
Role of adiposity-driven inflammation in depressive morbidity
L Capuron, J Lasselin, N Castanon - Neuropsychopharmacology, 2017 - nature.com
Depression and metabolic disorders, including overweight and obesity, appear tightly
interrelated. The prevalence of these conditions is concurrently growing worldwide, and both …
interrelated. The prevalence of these conditions is concurrently growing worldwide, and both …