The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

There is a strong need for science-based risk assessment that utilizes known data from
diverse sources to arrive at accurate assessments of human health risk. Such assessments …

Although we have greatly benefited from the use of traditional epidemiological approaches
in linking environmental exposure to human disease, we are still lacking knowledge in to …

Procedures for risk assessment of chemical mixtures, combined and cumulative exposures
are under development, but the scientific database needs considerable expansion. In …

Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently
accompanied by urothelial cell carcinomas of the upper urinary tract. This disorder has …

How mitochondria process DNA damage and whether a change in the steady-state level of
mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions …

Acrylamide (AA) was firstly detected in food in 2002, and since then, studies on AA analysis,
occurrence, formation, toxicity, risk assessment and mitigation have been extensively carried …

DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-
position of guanine. Ever since identification of the first N7-guanine adduct, several hundred …

Acrylamide (AA), a human neurotoxicant and rat tumorigen, is produced in starchy foods
when cooked. AA is also an industrial chemical used in polyacrylamide production. A safety …

Structural modifications of nucleobases within the deoxyribonucleic acid (DNA) of living cells
can be induced as a result of actions of specialized DNA-modifying enzymes (creating …