The interpretation and significance of DNA adduct data, their causal relationship to
mutations, and their role in risk assessment have been debated for many years. An …

This symposium focuses on the management of genotoxic impurities in the synthesis of
pharmaceuticals. Recent developments in both Europe and United States require sponsors …

DNA adducts represent an important category of biomarkers for detection and exposure
surveillance of potential carcinogenic and genotoxic chemicals in the environment. Sensitive …

Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans
through the metabolic oxidation of ethylene, generated during physiologic processes. EO is …

This study aimed at quantitatively comparing the occurrence/formation of DNA adducts with
the carcinogenicity induced by a selection of DNA-reactive genotoxic carcinogens. Contrary …

Acrylamide in cooked foods results in wide-spread, low-level human exposure. Potential
risks from dietary intake remain unclear due to apparent conflicting results from cancer …

Styrene is an important high production volume chemical used to manufacture polymeric
products. In 2018, International Agency for Research on Cancer classified styrene as …

For more than 40+ years, genotoxicity data have been interpreted in a qualitative, binary
mode; a chemical is considered either positive or negative for a response in the test system …

Acrylamide is commonly found in various foods. Cancer studies in rats have reported
increases in tumors of the thyroid, mammary tissues, tunica vaginalis of the testis, and …

Chiral pesticides with an asymmetrical center in their molecular structures possess
enantioselectivity, not only in their pesticidal activities toward targeted organisms but also in …