Lacidipine: a review of its use in the management of hypertension

PL McCormack, AJ Wagstaff - Drugs, 2003 - Springer
Summary Abstract Lacidipine (Caldine®, Lacimen®, Lacipil®, Midotens®, Motens®) is a
once-daily, orally-administered, lipophilic dihydropyridine calcium antagonist with an …

Ultra-performance liquid chromatography–tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic …

J Tang, R Zhu, R Zhao, G Cheng, W Peng - Journal of pharmaceutical and …, 2008 - Elsevier
A selective, rapid and sensitive ultra-performance liquid chromatography–tandem mass
spectrometry (UPLC–ESI-MS/MS) method was developed and validated for the …

Development of a supercritical fluid chromatography–tandem mass spectrometry method for the determination of lacidipine in beagle dog plasma and its application to …

Y Geng, L Zhao, J Zhao, B Guo, P Ma, Y Li… - … of Chromatography B, 2014 - Elsevier
A simple, novel, rapid and sensitive supercritical fluid chromatography–tandem mass
spectrometry (SFC-MS/MS) method was developed and validated for the determination of …

Photodegradation studies on lacidipine in solution: basic experiments with a cis–trans reversible photoequilibrium under UV-A radiation exposure

P De Filippis, E Bovina, L Da Ros, J Fiori… - … of pharmaceutical and …, 2002 - Elsevier
The photostability of Lacidipine, a dihydropyridine drug used in the treatment of mild and
moderate hypertension, was studied in solutions exposed to UV-A radiations. The effects of …

The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects

L Ziviani, L Da Ros, L Squassante… - British journal of …, 2001 - Wiley Online Library
Aims Lacidipine, a long acting 2, 4‐dihydropyridine calcium channel antagonist is frequently
administered with cholesterol lowering agents, particularly in elderly populations. The effects …

Development and validation of a liquid chromatographic method for determination of lacidipine residues on surfaces in the manufacture of pharmaceuticals

MJ Nozal, JL Bernal, JJ Jiménez, MT Martı́n… - … of Chromatography A, 2004 - Elsevier
A high-performance liquid chromatographic (HPLC) method for the assay of lacidipine
residues in swabs collected from various surfaces involved in drug manufacture is …

Simple, sensitive and rapid liquid chromatographic/electrospray ionization tandem mass spectrometric method for the quantification of lacidipine in human plasma

NVS Ramakrishna, KN Vishwottam… - Journal of mass …, 2004 - Wiley Online Library
A simple, sensitive and rapid liquid chromatographic/electrospray ionization tandem mass
spectrometric method was developed and validated for the quantification of lacidipine in …

Dose linearity of lacidipine pharmacokinetics after single and repeated oral doses in healthy volunteers

LD Ros, L Squassante, S Milleri - Clinical pharmacokinetics, 2003 - Springer
Objective To assess the dose proportionality of lacidipine after single and repeated oral
doses, and to obtain new information on the pharmacokinetics of the compound since …

LC‐MS/MS determination and pharmacokinetic study of lacidipine in human plasma

PK Chatki, KK Hotha, PRR Kolagatla… - Biomedical …, 2013 - Wiley Online Library
ABSTRACT A robust, specific and fully validated LC‐MS/MS method as per general
practices of industry has been developed for estimation of lacidipine (LAC) with 100 μL of …

The potential advantages of a modern antihypertensive therapy in the elderly

F Zannad - Journal of Cardiovascular Pharmacology, 2000 - journals.lww.com
More than 50% of hypertensive patients are aged above 65 years. Physiopathology of
essential hypertension is different in the elderly as compared with the young adult …