Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …

Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological
end point of cancer. We review here numerous affected oncogenes and metabolic pathways …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

In this review, the potential causes of ageing are discussed. We seek to gain insight into the
main physiological functions of mitochondria and discuss alterations in their function and the …

Major depression is a serious psychiatric disorder, occurring in up to 20% of the population.
Despite its devastating burden, the neurobiological changes associated with depression are …

Under physiological conditions 95% of the ingested essential amino acid tryptophan is
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …

Severe mental illnesses (SMI), including major depressive disorder, bipolar disorder, and
schizophrenia, are associated with increased inflammation. Given diet's role in modulating …

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …

Background: Metabolites of tryptophan, produced via the kynurenine pathway (kynurenines),
have been linked to Alzheimer's disease (AD) in small cohorts with conflicting results …

Pain is one of the main problems for modern society and medicine, being the most common
symptom described by almost all patients. When pain becomes chronic, the life of the …