Identification of active constituents and their molecular targets from traditional medicine is an
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …

Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Most cancer deaths are due to the systemic dissemination of cancer cells and the formation
of secondary tumors (metastasis) in distant organs. Recent years have brought impressive …

Breast cancer bone metastases (BCBM) result in serious skeletal morbidity. Although there
have been important advances in cancer treatment methods such as surgery and …

This study investigated Allium subhirsutum L.(AS) anticancer and antioxidant effects and
inhibition of tumor angiogenesis in a murine model of skeletal metastases due to inoculation …

Modern cancer therapies have significantly increased patient survival rates in both human
and veterinary medicine. Since cancer patients live longer they now face new challenges …

The malignant transformation of mesenchymal cells within the bone leads to the
development of osteosarcoma (OS), but the genetic underpinnings of these events are not …

The NF-κB signaling pathway is known to play an important role in the regulation of
osteoclastic bone resorption and cancer cell growth. Previous studies have shown that …

The majority of patients with terminal breast cancer show signs of bone metastasis, the most
common cause of pain in cancer. Clinically available drug treatment options for the relief of …