In vitro pharmacological profiling is increasingly being used earlier in the drug discovery
process to identify undesirable off-target activity profiles that could hinder or halt the …

Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Kratom, derived from the plant Mitragyna speciosa, is receiving increased attention as an
alternative to traditional opiates and as a replacement therapy for opiate dependence …

Intracranial self-stimulation (ICSS) is a behavioral procedure in which operant responding is
maintained by pulses of electrical brain stimulation. In research to study abuse-related drug …

We propose a new conceptual framework (computational validity) for translation across
species and populations based on the computational similarity between the information …

Sugar addiction: pushing the drug-sugar analogy to the limit : Current Opinion in Clinical
Nutrition & Metabolic Care Sugar addiction: pushing the drug-sugar analogy to the limit : Current …

Positive social interactions are essential for emotional well-being, healthy development,
establishment and maintenance of adequate social structures and reproductive success of …

The synthetic cathinones are derived from the naturally occurring drug cathinone found in
the khat plant (Catha edulis) and have chemical structures and neurochemical …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …