[HTML][HTML] Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention.

E Almanza-Aguilera, A Cano, M Gil-Lespinard… - Seminars in Cancer …, 2023 - Elsevier
Olive oil (OO) is the main source of added fat in the Mediterranean diet (MD). It is a mix of
bioactive compounds, including monounsaturated fatty acids, phytosterols, simple phenols …

[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

AB Behrooz, M Cordani, A Fiore, M Donadelli… - Seminars in Cancer …, 2024 - Elsevier
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

Obesity and multiple myeloma: Emerging mechanisms and perspectives

A Tentolouris, I Ntanasis-Stathopoulos… - Seminars in Cancer …, 2023 - Elsevier
Obesity is a global pandemic that has been associated with the development of breast,
endometrial, large intestine, renal, esophageal, and pancreatic cancer. Obesity is also …

Obesity and leukemia: biological mechanisms, perspectives, and challenges

D Tsilingiris, NG Vallianou, N Spyrou… - Current Obesity …, 2024 - Springer
Abstract Purpose of Review To examine the epidemiological data on obesity and leukemia;
evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic …

Obesity, dietary fats, and gastrointestinal cancer risk-potential mechanisms relating to lipid metabolism and inflammation

KAJ Mitchelson, F O'Connell, J O'Sullivan, HM Roche - Metabolites, 2024 - mdpi.com
Obesity is a major driving factor in the incidence, progression, and poor treatment response
in gastrointestinal cancers. Herein, we conducted a comprehensive analysis of the impact of …

Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma

X Zhang, Y Gao, K Tang, Z Li… - American Journal …, 2024 - journals.physiology.org
Several clinical studies observed a surprising beneficial effect of obesity on enhancing
immunotherapy responsiveness in patients with melanoma, highlighting an as-yet …

Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma

X Zhang, WD Lee, BP Leitner, W Zhu… - American Journal …, 2023 - journals.physiology.org
Cancer-related fatigue (CRF) is one of the most common complications in patients with
multiple cancer types and severely affects patients' quality of life. However, there have only …

Inorganic Nanoparticles Change Cancer-Cell-Derived Extracellular Vesicle Secretion Levels and Cargo Composition, Resulting in Secondary Biological Effects

K Buttiens, C Maksoudian, I Perez Gilabert… - … Applied Materials & …, 2024 - ACS Publications
Over the past decades, the medical exploitation of nanotechnology has been largely
increasing and finding its way into translational research and clinical applications. Despite …

Embryonic programs in cancer and metastasis—insights from the mammary gland

MY Lee - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Cancer is characterized as a reversion of a differentiated cell to a primitive cell state that
recapitulates, in many aspects, features of embryonic cells. This review explores the current …

Insulin Resistance: The Increased Risk of Cancers

L Szablewski - Current Oncology, 2024 - mdpi.com
Insulin resistance, also known as impaired insulin sensitivity, is the result of a decreased
reaction of insulin signaling to blood glucose levels. This state is observed when muscle …