Despite several decades of research, current antidepressant (AD) treatments remain of a
limited efficacy justifying the need to find new drugs. These drugs have to be more …

The ability to sense pain signals is closely linked to the activity of ion channels expressed in
nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion …

Twik-related K+ (TREK) channels produce background currents that regulate cell excitability.
In vivo, TREK-1 is involved in neuronal processes including neuroprotection against …

The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …

Two-pore domain potassium (K 2P) channels have a distinct structure and channel
properties, and are involved in a background K+ current. The 15 members of the K 2P …

Traumatic early life stress (ELS) is linked to dopamine (DA) dysregulation which increases
the probability of developing psychiatric disorders in adolescence and adulthood. Our prior …

Depression is a devastating mood disorder and a leading cause of disability worldwide.
Depression affects approximately one in five individuals in the world and represents heavy …

Abstract TWIK-related potassium channel-1 (TREK1, KCNK2) is the most extensively studied
member of the two-pore domain potassium (K 2P) channel family. Recent studies have …

K2P channels, also known as two-pore domain K+ channels, play a crucial role in
maintaining the cell membrane potential and contributing to potassium homeostasis due to …

TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli,
including bioactive lipids, mechanical stretch and temperature, into electrical signals. The …