Identification of a region in the TASK3 two pore domain potassium channel that is critical for its blockade by methanandamide
EL Veale, R Buswell, CE Clarke… - British journal of …, 2007 - Wiley Online Library
Background and purpose: The TASK subfamily of two pore domain potassium channels
(K2P) encodes for leak K currents, contributing to the resting membrane potential of many …
(K2P) encodes for leak K currents, contributing to the resting membrane potential of many …
Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel
RG Zhuo, XY Liu, SZ Zhang, XL Wei, JQ Zheng, JP Xu… - Neuroscience, 2015 - Elsevier
Aminoethoxydiphenyl borate (2-APB) has been recently identified as a common agonist of
TWIK-related K+ channel (TREK)/TRAAK channels, a subfamily of two-pore domain K+(K2P) …
TWIK-related K+ channel (TREK)/TRAAK channels, a subfamily of two-pore domain K+(K2P) …
[HTML][HTML] Tandem pore TWIK-related potassium channels and neuroprotection
JA Lamas, D Fernández-Fernández - Neural Regeneration …, 2019 - journals.lww.com
TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain
potassium channels family with three members, TREK1, TREK2 and TWIK-related …
potassium channels family with three members, TREK1, TREK2 and TWIK-related …
[HTML][HTML] A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
CA Amaya-Rodriguez, K Carvajal-Zamorano… - Frontiers in …, 2024 - frontiersin.org
The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …
Sortilin‐Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain
W Sun, F Yang, Y Wang, Y Yang, R Du… - Advanced …, 2024 - Wiley Online Library
Neuropathic pain can occur during the prediabetic stage, even in the absence of
hyperglycemia. The presence of prediabetic neuropathic pain (PDNP) poses challenges to …
hyperglycemia. The presence of prediabetic neuropathic pain (PDNP) poses challenges to …
[HTML][HTML] A potential role for a genetic variation of AKAP5 in human aggression and anger control
S Richter, X Gorny, J Marco-Pallares… - Frontiers in human …, 2011 - frontiersin.org
The A-kinase-anchoring protein 5 (AKAP5), a post-synaptic multi-adaptor molecule that
binds G-protein-coupled receptors and intracellular signaling molecules has been …
binds G-protein-coupled receptors and intracellular signaling molecules has been …
[HTML][HTML] Tubulin Binds to the Cytoplasmic Loop of TRESK Background K+ Channel In Vitro
P Enyedi, I Veres, G Braun, G Czirjak - PLoS One, 2014 - journals.plos.org
The cytoplasmic loop between the second and third transmembrane segments is pivotal in
the regulation of TRESK (TWIK-related spinal cord K+ channel, K2P18. 1, KCNK18) …
the regulation of TRESK (TWIK-related spinal cord K+ channel, K2P18. 1, KCNK18) …
[HTML][HTML] Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors
IM Brooks, SJ Tavalin - Journal of biological chemistry, 2011 - ASBMB
GluA1 (formerly GluR1) AMPA receptor subunit phosphorylation at Ser-831 is an early
biochemical marker for long-term potentiation and learning. This site is a substrate for Ca …
biochemical marker for long-term potentiation and learning. This site is a substrate for Ca …
[HTML][HTML] Convergence of multiple stimuli to a single gate in TREK1 and TRAAK potassium channels
FS Choveau, I Ben Soussia, D Bichet… - Frontiers in …, 2021 - frontiersin.org
Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli,
including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these …
including temperature, membrane stretch, polyunsaturated fatty acids and pH. How these …
Prolonged exposure to lactate causes TREK1 channel clustering in rat hippocampal astrocytes
Abstract Increased concentrations of lactate (15–30 mM) are associated with and found to
be neuroprotective in various brain pathophysiology. In our earlier studies we showed that …
be neuroprotective in various brain pathophysiology. In our earlier studies we showed that …