Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …

The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

TNF is a master pro-inflammatory cytokine. Activation of TNFR1 by TNF can result in both
RIPK1-independent apoptosis and RIPK1 kinase-dependent apoptosis or necroptosis …

The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed
of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also …

Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …

The link between chronic inflammation and cancer involves cytokines and mediators of
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism …

The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related
kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation …