Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

Biofilms in chronic wound infections: innovative antimicrobial approaches using the in vitro Lubbock chronic wound biofilm model

F Diban, S Di Lodovico, P Di Fermo, S D'Ercole… - International journal of …, 2023 - mdpi.com
Chronic wounds have harmful effects on both patients and healthcare systems. Wound
chronicity is attributed to an impaired healing process due to several host and local factors …

[HTML][HTML] Current developments in biofilm treatments: Wound and implant infections

Y Dhar, Y Han - Engineered Regeneration, 2020 - Elsevier
Biofilm formation in wounds and implants can have numerous negative effects on a patient's
health, including delayed healing and implant removal. Current treatments for biofilms do …

Imitating the microenvironment of native biofilms using nanofibrous scaffolds to emulate chronic wound infections

J Wächter, PK Vestweber, N Jung… - Journal of Materials …, 2023 - pubs.rsc.org
Three-dimensional scaffolds of electrospun fibers are widely investigated for in vitro human
tissue engineering, but to date, their application in the cultivation of bacterial biofilms has …

In vitro models of bacterial biofilms: innovative tools to improve understanding and treatment of infections

G Crivello, L Fracchia, G Ciardelli, M Boffito, C Mattu - Nanomaterials, 2023 - mdpi.com
Bacterial infections are a growing concern to the health care systems. Bacteria in the human
body are often found embedded in a dense 3D structure, the biofilm, which makes their …

Plasma medicine and wound management: Evaluation of the antibacterial efficacy of a medically certified cold atmospheric argon plasma jet

I Plattfaut, M Besser, AL Severing, EK Stürmer… - International Journal of …, 2021 - Elsevier
Objectives: A major problem for wound healing is contamination with bacteria, often
resulting in biofilm formation and wound infection, which, in turn, needs immediate …

Composition of challenge substance in standardized antimicrobial efficacy testing of wound antimicrobials is essential to correctly simulate efficacy in the human …

AL Severing, M Borkovic, EK Stuermer, JD Rembe - Biomedicines, 2022 - mdpi.com
Current standards insufficiently acknowledge the influence of the wound micro-environment
on the efficacy of antimicrobial agents. To address this, octenidine/phenoxyethanol …

In vitro Activity of Antimicrobial Wound Dressings on P. aeruginosa Wound Biofilm

EK Stuermer, I Plattfaut, M Dietrich, F Brill… - Frontiers in …, 2021 - frontiersin.org
The treatment of acute and chronic infected wounds with residing biofilm still poses a major
challenge in medical care. Interactions of antimicrobial dressings with bacterial load, biofilm …

Robbing Peter to Pay Paul: Chlorhexidine gluconate demonstrates short‐term efficacy and long‐term cytotoxicity

JZA Cheong, A Liu, CJ Rust, CL Tran… - Wound Repair and …, 2022 - Wiley Online Library
Wound cleansing agents are routine in wound care and preoperative preparation. Antiseptic
activity intends to prevent contaminating microbes from establishing an infection while also …

[HTML][HTML] Pulsed low-intensity laser treatment stimulates wound healing without enhancing biofilm development in vitro

M Besser, L Schaeler, I Plattfaut, FHH Brill… - … of Photochemistry and …, 2022 - Elsevier
Objectives Treating infected or chronic wounds burdened with biofilms still is a major
challenge in medical care. Healing-stimulating factors lose their efficacy due to bacterial …