Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Trained immunity: adaptation within innate immune mechanisms

J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

[HTML][HTML] Innate lymphoid cells: 10 years on

E Vivier, D Artis, M Colonna, A Diefenbach, JP Di Santo… - Cell, 2018 - cell.com
Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified
antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and …

Structure and function of the immune system in the spleen

SM Lewis, A Williams, SC Eisenbarth - Science immunology, 2019 - science.org
The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …

The crosstalk between tumor cells and the immune microenvironment in breast cancer: implications for immunotherapy

V Salemme, G Centonze, F Cavallo, P Defilippi… - Frontiers in …, 2021 - frontiersin.org
Breast cancer progression is a complex process controlled by genetic and epigenetic factors
that coordinate the crosstalk between tumor cells and the components of tumor …

Interleukin‐33 (IL‐33): a nuclear cytokine from the IL‐1 family

C Cayrol, JP Girard - Immunological reviews, 2018 - Wiley Online Library
Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Therapeutic targeting of trained immunity

WJM Mulder, J Ochando, LAB Joosten… - Nature reviews Drug …, 2019 - nature.com
Immunotherapy is revolutionizing the treatment of diseases in which dysregulated immune
responses have an important role. However, most of the immunotherapy strategies currently …

[HTML][HTML] NK cells and ILCs in tumor immunotherapy

S Sivori, D Pende, L Quatrini, G Pietra… - Molecular aspects of …, 2021 - Elsevier
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

TH2 cell development and function

JA Walker, ANJ McKenzie - Nature Reviews Immunology, 2018 - nature.com
Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

Y Huang, K Mao, X Chen, M Sun, T Kawabe, W Li… - Science, 2018 - science.org
Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …