Tubulin-interactive natural products as anticancer agents

DGI Kingston - Journal of natural products, 2009 - ACS Publications
This review provides an overview of the discovery, structures, and biological activities of
anticancer natural products that act by inhibiting or promoting the assembly of tubulin to …

Potential of plant-derived natural products in the treatment of leukemia and lymphoma

DM Lucas, PC Still, L Bueno Perez… - Current drug …, 2010 - ingentaconnect.com
Hematologic malignancies account for a substantial percentage of cancers worldwide, and
the heterogeneity and biological characteristics of leukemias and lymphomas present …

Natural bioactive lead compounds effective against haematological malignancies

AM Găman, C Egbuna, MA Găman - … as lead compounds for new drug …, 2020 - Elsevier
The treatment of hematological diseases has evolved tremendously during the past
decades. The discovery of new drugs has permitted us to target even the most subtle …

Electrochemical evaluation and determination of vindesine used in cancer chemotherapy at disposable pencil graphite electrode by voltammetric method

G Önal, A Levent - Monatshefte für Chemie-Chemical Monthly, 2023 - Springer
Here, the electrochemical properties and detection of vindesine on the working electrode
surface of disposable pencil graphite electrode were determined by cyclic voltammetry and …

[HTML][HTML] Cell death signaling and anticancer therapy

L Galluzzi, I Vitale, E Vacchelli, G Kroemer - Frontiers in oncology, 2011 - frontiersin.org
For a long time, it was commonly believed that efficient anticancer regimens would either
trigger the apoptotic demise of tumor cells or induce a permanent arrest in the G1 phase of …

Natural products as pharmaceuticals and sources for lead structures

DJ Newman, GM Cragg, DGI Kingston - The practice of medicinal …, 2008 - Elsevier
Publisher Summary Plant-based systems continue to play an essential role in health care,
and their use by different cultures is extensively documented. This chapter reviews the …

Inadvertent intrathecal injections and best practice management

H Liu, R Tariq, GL Liu, H Yan… - Acta Anaesthesiologica …, 2017 - Wiley Online Library
The intrathecal space has become an important anatomic site for medical intervention not
only in anesthesia practice, but also in many other medical specialties …

Plant secondary metabolites in cancer chemotherapy: where are we?

DM Pereira, P Valentao… - Current …, 2012 - ingentaconnect.com
Nowadays we have a number of chemical and biological agents at our disposal to treat
chronic pathologies such as cancer. Although most drugs display significant activity, thus …

Anticancer prodrugs: An overview of major strategies and recent developments

S Arpicco, F Dosio, B Stella… - Current topics in medicinal …, 2011 - ingentaconnect.com
Research in anticancer chemotherapy has produced outstanding results, and mean survival
rates have significantly improved over the last ten years. Nevertheless, all approved drugs …

Synthesis and fungicidal activity of quinolin-6-yloxyacetamides, a novel class of tubulin polymerization inhibitors

C Lamberth, FM Kessabi, R Beaudegnies… - Bioorganic & Medicinal …, 2014 - Elsevier
A novel class of experimental fungicides has been discovered, which consists of special
quinolin-6-yloxyacetamides. They are highly active against important phytopathogens, such …